2019 Novel Coronavirus

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If vaccinespotter isn't working, try this: TurboVax (I'm sure you already know about it, but just in case!!)
Thanks, issue is I am not actually eligible until Monday so there is a network of official vaccine centers I can't see until then but I have seen two open appointent through RiteAid from the vaccinespotter site. The appointments just move so fast that by the time these sites report an opening, it's gone.
 
Vax appointment this afternoon. Was registered on four different wait lists.

Hoping for ability to fly, maybe adamantium claws
To be fair, adamantium claws/skeleton aren’t really a mutant ability. Your best bet is healing powers and then hope some secret Gov’t organization can hook you up with claws.

I get the J&J shot on Sunday. Hopefully the superpower potential is still there with the single shot.
 
To be fair, adamantium claws/skeleton aren’t really a mutant ability. Your best bet is healing powers and then hope some secret Gov’t organization can hook you up with claws.

I get the J&J shot on Sunday. Hopefully the superpower potential is still there with the single shot.
I know the claws just seem really cool.

Given the amount of pipe locating I have done in my career, the most useful superpower for work related reasons would be x-ray vision.
 
Dang. Covid is still a thing? Haven't really heard or dealt with it much after moving down to FL.
 
Don't even get me started. Every time the CDC/Fauci opens their mouth, it makes me think they're only concerned with spreading panic and staying in the spotlight.

According to Johns Hopkins, CVST (the blood clots they're talking about) is rare but affects 5 out of 1,000,000 every year. There have been 6.8 million doses of the J&J vaccine given out meaning there's a very real potential for 34 people in that group to develop blood clots. They're "pausing" the vaccine because six people developed blood clots....6.

https://www.hopkinsmedicine.org/health/conditions-and-diseases/cerebral-venous-sinus-thrombosis
 
CBS News: People who just got the Johnson & Johnson vaccine are worried. What should they look out for?

Dr. Anthony Fauci: Well, it depends on when they got it. It appears that this adverse event occurs between six days and 13 days. So if you've had it a month or two ago, I think you really don't need to worry about anything. If you are in the time frame of within a week or two of having gotten vaccinated, remember one thing: This is a very rare event. It's less than one in a million.

Source: Dr. Anthony Fauci on what the Johnson & Johnson vaccine reactions could mean for women

CDC Statement:

CDC will convene a meeting of the Advisory Committee on Immunization Practices (ACIP) on Wednesday to further review these cases and assess their potential significance. FDA will review that analysis as it also investigates these cases. Until that process is complete, we are recommending a pause in the use of this vaccine out of an abundance of caution. This is important, in part, to ensure that the health care provider community is aware of the potential for these adverse events and can plan for proper recognition and management due to the unique treatment required with this type of blood clot.

Right now, these adverse events appear to be extremely rare. COVID-19 vaccine safety is a top priority for the federal government, and we take all reports of health problems following COVID-19 vaccination very seriously.

Source: Coronavirus Disease 2019
 
Don't even get me started. Every time the CDC/Fauci opens their mouth, it makes me think they're only concerned with spreading panic and staying in the spotlight.

According to Johns Hopkins, CVST (the blood clots they're talking about) is rare but affects 5 out of 1,000,000 every year. There have been 6.8 million doses of the J&J vaccine given out meaning there's a very real potential for 34 people in that group to develop blood clots. They're "pausing" the vaccine because six people developed blood clots....6.

https://www.hopkinsmedicine.org/health/conditions-and-diseases/cerebral-venous-sinus-thrombosis
You're not wrong, but it is a little more complex than that.

All medicines are required to disclose all possible adverse side effects, which required extensive research and testing. This side effect was not disclosed by J&J. Protocol dictates that they have to pause use to (1) determine if this was missed or was it intentionally hidden, (2) assess if anything else was missed or intentionally hidden, (3) update all paperwork, procedures, risks assessments etc so doctors have all necessary info when deciding how to treat their patients.

The J&J vaccine has proved to be effective and this side effect is exceeding rare. It's expected that they can get through this process and un-pause the use very soon. But due diligence is required.
 
For reporting of side effects, is there any threshold for statistical significance?
 
Got my 2nd shot yesterday. Woohoo!!! The arm hurts worse than after the first but otherwise no other issues here. I tired today, but we ate dinner really late so I stayed up later than usual. so I can't attribute it to the shot.
 
Got my 2nd shot yesterday. Woohoo!!! The arm hurts worse than after the first but otherwise no other issues here. I tired today, but we ate dinner really late so I stayed up later than usual. so I can't attribute it to the shot.
About 6 hours into shot #2 here, and so far, just a bit tired, mild headache, and a sore arm. Cautiously optimistic!
 
For reporting of side effects, is there any threshold for statistical significance?
That's a good question. I don't know. (But I know someone I could ask.)

From what I understand, anything that happens to any trial participants during the trial has to be reported. So even if there's no stated statistical cutoff, there would be a de-facto cutoff just because trials only have so many people in them. If the trial was thousands or 10's of thousand of people, but not millions, everything could have been done correctly and this could have still been missed.

It's also interesting to me that all of the people who experience blood clots are women.

Historically sex as a biological variable (SABV) has been ignored in research studies. Interestingly, most of the drug recalls in the last couple of decades have been because of women-specific side effects that weren't discovered during trials. Human trials are pretty even between men and women today, but animal trials (which is the first step for almost all research) typically uses male animals, simply because boy mice are cheaper to purchase than girl mice. Also most of the cell lines that scientist use for research are male cells. Awareness has been growing over this as a major oversight in science.

In the past few years the US National Institute of Health, the European Commission, and the Canadian Institute of Health Research have all instituted SABV policies. Some scientific journals have stopped publishing research where SABV isn't considered. So things are improving, but I'm curious if this is related to this specific J&J blood clotting issue.

Anyway, I went off on a tangent, but if you want to learn more.



https://orwh.od.nih.gov/sex-gender/nih-policy-sex-biological-variable
https://en.wikipedia.org/wiki/Sex_as_a_biological_variable
 
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